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Rabbit Anti-Mouse Glucokinase Regulatory Protein (GKRP) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse glucokinase regulatory protein. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse glucokinase regulatory protein.
Specifications
Target Information
Mouse glucokinase regulatory protein (GKRP) is a 626-residue nucleocytoplasmic shuttling protein that binds hepatic glucokinase (GCK) in the nucleus under low-glucose conditions. Its N-terminal 18-residue tail contains a bipartite nuclear-localization signal, while a central 300-residue GCK-binding domain forms a hydrophobic pocket that stabilizes the inactive enzyme conformation. Expressed almost exclusively in liver and pancreatic islets, GKRP localizes to hepatocyte nuclei and translocates to the cytoplasm at high glucose concentrations. Antibodies raised against full-length or N-terminal peptide detect native, phosphorylated and ubiquitinated isoforms with negligible cross-reactivity to GCK or other nuclear receptors, enabling selective immunoblot and immunofluorescence analysis in mouse liver homogenates and cultured hepatocytes.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.