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Rabbit Anti-Mouse Frataxin (FXN) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse frataxin. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse frataxin.
Specifications
Target Information
Mouse frataxin (FXN) is a 18-kDa mitochondrial protein ubiquitously expressed in murine tissues, with enriched levels in heart, liver, and skeletal muscle. It functions as a chaperone for iron-sulfur cluster (ISC) biosynthesis, regulating mitochondrial iron homeostasis and protecting against iron-induced oxidative stress. Critical for mitochondrial respiratory chain function, energy metabolism, and cellular viability in mice, its deficiency impairs ISC-dependent enzyme activity, leading to mitochondrial dysfunction. Dysregulated expression associates with Friedreich's ataxia, cardiomyopathy, and neurodegeneration in murine models. As a key mediator of mitochondrial iron metabolism and ISC biogenesis, mouse FXN is a critical target for studying mitochondrial pathobiology, neurodegenerative diseases, and protein replacement therapeutics.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.