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Rabbit Anti-Mouse Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3 (EIF2aK3) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse eukaryotic translation initiation factor 2 alpha kinase 3. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse eukaryotic translation initiation factor 2 alpha kinase 3.
Specifications
Target Information
Mouse eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3), also known as PERK, is a critical serine/threonine kinase in the integrated stress response. Activated by endoplasmic reticulum stress, it phosphorylates EIF2α, transiently attenuating global protein synthesis while enhancing translation of stress-related mRNAs. Predominantly localized to the ER membrane, EIF2AK3 is essential for maintaining cellular homeostasis, regulating autophagy, apoptosis, and metabolic adaptation. Its expression is ubiquitous, with notable abundance in secretory tissues. Antibodies targeting EIF2AK3 are valuable tools for investigating ER stress signaling, unfolded protein response pathways, and metabolic disorders in murine model systems.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.