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Rabbit Anti-Mouse Elongin A (ELOA) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse elongin A. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse elongin A.
Specifications
Target Information
Mouse elongin A (EloA) is a 773-residue transcriptional elongation factor composed of an N-terminal BC-box (residues 110-120) that binds Cul5/Rbx2, a central ubiquitin-like domain, and a C-terminal region that docks RNA polymerase II and TFIIH. The protein forms a stable heterotrimer with elongins B and C, increasing polymerase processivity by suppressing transient pausing. Expressed ubiquitously in liver, brain and kidney, elongin A localizes to nuclear speckles and active transcription sites. Antibodies raised against the BC-box or C-terminal peptide detect native, phosphorylated and ubiquitinated isoforms with negligible cross-reactivity to elongin B or C, enabling precise immunoblot and immunofluorescence analysis in mouse tissue homogenates and cultured cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.