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Rabbit Anti-Mouse Diacylglycerol Kinase Zeta (DGKz) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse diacylglycerol kinase zeta. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse diacylglycerol kinase zeta.
Specifications
Target Information
Mouse diacylglycerol kinase zeta (DGKζ) is a cytoplasmic serine/threonine kinase of the DGK family, a core regulator of lipid signaling and intracellular second messenger homeostasis. It features a conserved N-terminal catalytic domain with ATP-binding motif, tandem cysteine-rich C1 domains for diacylglycerol (DAG) binding, and a C-terminal PDZ-binding motif critical for protein-protein interaction. It localizes to the cytoplasm and plasma membrane of mouse immune, neuronal and epithelial cells, with negligible levels in terminally differentiated tissues. The protein mediates DAG phosphorylation to phosphatidic acid (PA), with conserved motifs for modulating PKC and Ras signaling pathways. Mouse DGKζ shares core functional domains with mammalian orthologs, and has distinct tissue specificity differentiating it from DGKα and DGKε.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.