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Rabbit Anti-Mouse Cluster of Differentiation 8a (CD8a) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse cluster of differentiation 8a. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse cluster of differentiation 8a.
Specifications
Target Information
Mouse CD8a is a 24 kDa type-I transmembrane glycoprotein whose Ig-like V-set domain locks onto MHC-I, while a short cytoplasmic tail couples to Lck for T-cell activation. A solvent-exposed 14-aa "KVE" loop (aa 95-108) between β-strands C and C' folds into a β-hairpin unique among mouse CD8 alleles, presenting a fixation-stable epitope absent from CD8b. Affinity-purified antibodies targeting this loop trace native CD8a in thymic cortex, splenic cytotoxic T cells, and intraepithelial lymphocytes, delivering crisp surface rings and single-band clarity on immunoblots with no cross-reaction to CD4 or CD8b.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.