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Rabbit Anti-Mouse Cluster of Differentiation 72 (CD72) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse cluster of differentiation 72. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse cluster of differentiation 72.
Specifications
Target Information
Mouse cluster of differentiation 72 (CD72) is a 359-residue type II transmembrane glycoprotein whose extracellular C-terminal region carries two C-type lectin-like domains that bind CD100 (Semaphorin-4D). A single transmembrane helix anchors the protein to B-cell and dendritic-cell plasma membranes, while a 61-aa N-terminal cytoplasmic tail contains two ITIM motifs that recruit SHP-1 and SHP-2 upon phosphorylation. Constitutively expressed in spleen, lymph node and bone-marrow, CD72 localizes to lipid rafts and the immunological synapse. Antibodies raised against the lectin-like or cytoplasmic peptide detect native, glycosylated and phosphorylated isoforms with negligible cross-reactivity to other lectin receptors, enabling selective immunoblot and immunofluorescence analysis in mouse lymphoid tissue homogenates and cultured immune cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.