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Rabbit Anti-Mouse Cluster of Differentiation 28 (CD28) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse cluster of differentiation 28. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse cluster of differentiation 28.
Specifications
Target Information
Mouse cluster of differentiation 28 (CD28) is a 243-residue type I transmembrane glycoprotein whose extracellular V-like Ig domain (residues 20-120) binds the MYPPPY motif in B7-1 (CD80) and B7-2 (CD86). A single transmembrane helix anchors the protein to T-cell surfaces, while a 41-aa cytoplasmic tail carries two YXN motifs that recruit PI3K and GRB2 after phosphorylation. Constitutively expressed on CD4⁺ and CD8⁺ T cells, CD28 localizes to the immunological synapse and microvilli. Antibodies raised against the IgV or cytoplasmic peptide detect native, glycosylated and phosphorylated isoforms with negligible cross-reactivity to CTLA-4 or other CD28 family members, enabling selective immunoblot and immunofluorescence analysis in mouse lymphoid tissue homogenates and cultured T cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.