Rabbit Anti-Mouse Cathepsin Z (CTSZ) Polyclonal Antibody

Mouse cathepsin Z (CTSZ) is a 38-kDa cysteine protease localized to murine lysosomes and cell surfaces, with enriched expression in immune cells (macrophages, neutrophils), kidney, and tumor tissues. It mediates proteolytic cleavage of extracellular matrix proteins, cytokines, and cell surface receptors, regulating processes including cell migration, invasion, and immune response. Critical for murine tissue remodeling, wound healing, and host defense, it modulates inflammatory signaling and lysosomal protein turnover. Dysregulated expression associates with cancer metastasis, inflammatory disorders (e.g., arthritis), and lysosomal storage defects in mouse models. As a key mediator of proteolytic remodeling and immune regulation, mouse CTSZ is a critical target for studying cancer progression, inflammatory pathobiology, and protease-targeted therapeutics.