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Rabbit Anti-Mouse Caspase 12 (CASP12) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse caspase 12. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse caspase 12.
Specifications
Target Information
Mouse caspase 12 is a 373-residue inflammatory caspase comprising an N-terminal CARD (caspase recruitment domain), a central catalytic subunit with the conserved QACRG active-site pentad, and a C-terminal region that undergoes proteolytic removal during activation. The protein localizes to the endoplasmic reticulum outer membrane via its CARD, where it forms filaments through homotypic CARD interactions. Constitutively expressed in liver, kidney and lung, caspase 12 cycles between inactive monomers and activated oligomers. Antibodies raised against the CARD or large-subunit peptide detect native, cleaved and polymerized forms with negligible cross-reactivity to caspase 1 or 11, enabling selective immunoblot and immunofluorescence visualization in mouse tissue homogenates and cultured cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.