This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Rabbit Anti-Mouse Breast Cancer Susceptibility Protein 1 (BRCA1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse breast cancer susceptibility protein 1. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse breast cancer susceptibility protein 1.
Specifications
Target Information
Mouse breast cancer susceptibility protein 1 (BRCA1) is a 1,812-residue nuclear phosphoprotein harboring an N-terminal RING finger with E3 ubiquitin ligase activity, two centrally located BRCA1 C-terminal (BRCT) repeats that bind phosphorylated peptides, and multiple SQ/TQ clusters targeted by ATM/ATR kinases. The polypeptide assembles into heterodimers with BARD1, stabilizing the RING domain and enhancing ligase catalysis. Expression peaks during S and G2 phases, localizing to DNA damage foci, centrosomes and replication forks. Antibodies generated against full-length or peptide epitopes of mouse BRCA1 detect both native and phosphorylated isoforms with negligible cross-reactivity to BRCA2 or other RING proteins, enabling specific visualization in nuclear extracts and fixed tissue sections.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.