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Rabbit Anti-Mouse Asialoglycoprotein Receptor 1 (ASGR1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse asialoglycoprotein receptor 1. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse asialoglycoprotein receptor 1.
Specifications
Target Information
Mouse asialoglycoprotein receptor 1 (ASGR1) is a 284-residue type II transmembrane glycoprotein that assembles with ASGR2 into a hetero-oligomeric lectin complex. Its extracellular carbohydrate-recognition domain binds terminal galactose or N-acetylgalactosamine residues via a conserved Ca²⁺-coordinating site, while a short N-terminal cytoplasmic tail contains a tyrosine-based internalization motif. Expressed almost exclusively on hepatocyte sinusoidal membranes, ASGR1 localizes to clathrin-coated pits and recycling endosomes. Antibodies raised against the ectodomain or cytoplasmic peptide detect native, glycosylated and truncated forms with negligible cross-reactivity to ASGR2 or other C-type lectins, enabling selective immunoblot and immunohistochemical visualization in mouse liver homogenates and sections.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.