This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Rabbit Anti-Mouse Anoctamin 1 (ANO1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse anoctamin 1. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse anoctamin 1.
Specifications
Target Information
Mouse anoctamin 1 (ANO1) is an 887-residue eight-span membrane protein that assembles as a dimer to form Ca²⁺-activated chloride channels. Each subunit contains a conserved "E-EEEE" cytoplasmic motif that coordinates cytosolic Ca²⁺ and triggers pore opening via helix repositioning within transmembrane segments 6 and 7. Constitutively expressed in airway epithelium, salivary glands, dorsal root ganglia and interstitial cells of Cajal, ANO1 localizes to plasma membrane and intracellular vesicles. Antibodies raised against the third extracellular loop or C-terminal tail detect native glycosylated and unglycosylated isoforms with negligible cross-reactivity to ANO2-ANO10, enabling selective immunoblot, immunohistochemistry and flow-cytometric analysis in mouse tissue homogenates and cultured cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.