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Rabbit Anti-Mouse Alpha-1-Antichymotrypsin (a1ACT) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse alpha-1-antichymotrypsin. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse alpha-1-antichymotrypsin.
Specifications
Target Information
Mouse alpha-1-antichymotrypsin (Serpina3) is a 398-residue, 68 kDa secreted glycoprotein belonging to the clade A serpin superfamily. Synthesized primarily in hepatocytes and activated astrocytes, the molecule presents a mobile reactive-center loop (P1-P1' = Leu-Ser) that traps target chymotrypsin-like proteases through rapid formation of a 1:1 stable acyl-enzyme complex followed by loop insertion into β-sheet A. Two N-linked glycans shield the hydrophobic breach region, while a single disulfide bridges residues 256-277. Antibodies raised against native or peptide epitopes of mouse Serpina3 detect intact, cleaved and polymerized forms with negligible cross-reactivity to Serpina1 or other serpins, enabling precise immunoblot and immunohistochemical localization in mouse plasma and tissue sections.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.