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Rabbit Anti-Mouse Activating Transcription Factor 4 (ATF4) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse activating transcription factor 4. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse activating transcription factor 4.
Specifications
Target Information
Mouse activating transcription factor 4 (ATF4) is a 43 kDa bZIP protein whose N-terminal kinase-inducible domain recruits cofactors while its C-terminal DNA-binding groove clamps CRE/ATF motifs, driving stress-responsive transcription. A solvent-exposed 16-aa "QEL" hinge (aa 165-180) links the two modules, folding into a β-hairpin unique among ATF family members; this epitope survives aldehyde fixation and antigen retrieval. Affinity-purified antibodies targeting this hinge trace native ATF4 in hippocampal nuclei, splenic lymphocytes, and stress granules, delivering crisp punctate staining and single-band clarity on immunoblots with no cross-reaction to ATF2 or CREB.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.