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Rabbit Anti-Chicken Complement Component 4 (C4) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for chicken complement component 4. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of chicken complement component 4.
Specifications
Target Information
Chicken complement component 4 (C4) is a 1,730-residue plasma glycoprotein synthesized as a single-chain proprotein that undergoes proteolytic maturation into three disulfide-linked chains: α (93 kDa), β (70 kDa) and γ (30 kDa). The α-chain contains a buried thioester bond (Cys-Gly-Glu-Gln) that becomes exposed upon C1s cleavage, allowing covalent attachment to target surfaces. Constitutively expressed in liver and secreted into serum, C4 localizes to immune complexes and cell membranes during activation. Antibodies raised against the α-chain or thioester-containing region detect native, cleaved and activated forms with negligible cross-reactivity to C3 or C5, enabling selective immunoblot and immunohistochemical visualization in chicken plasma and tissue sections.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.