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Rabbit Anti-Canine Vascular Endothelial Growth Factor B (VEGFB) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for canine vascular endothelial growth factor B. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of canine vascular endothelial growth factor B.
Specifications
Target Information
Canine vascular endothelial growth factor B (VEGF-B) is a secreted glycoprotein of the VEGF family, a key regulator of vascular homeostasis and lipid metabolism in endothelial cells. It features conserved N-terminal VEGF homology domains, a cysteine-knot motif for dimerization, and a C-terminal domain critical for receptor binding and specificity. It localizes to the extracellular matrix of canine cardiac, skeletal muscle and vascular tissues, with negligible levels in non-vascular and epithelial tissues. The protein mediates VEGFR-1 activation and endothelial cell survival, with conserved motifs for binding to heparan sulfate proteoglycans. Canine VEGF-B shares core functional domains with mammalian orthologs, and has distinct tissue distribution differentiating it from VEGF-A and VEGF-C.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.