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Porcine Endoplasmin (HSP90B1) ELISA Kit-Sandwich

Name: Porcine Endoplasmin (HSP90B1) ELISA Kit-Sandwich
SKU: EK12F495
Rating: 5 (1 reviews)

Cat. No.EK12F495

Product TypeAnimal Immunoassay Kits

Size

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Product Overview

BioVenic Porcine Endoplasmin (HSP90B1) ELISA Kit-Sandwich is designed for the quantitative determination of Porcine Endoplasmin (HSP90B1) in serum, plasma, tissue homogenate, cell culture supernatant, cell extract, and other biological fluids using a Sandwich ELISA method. For research use only.

Specifications

Assay Type ELISA-Sandwich

Specificity The assay kit is specific for Porcine HSP90B1.

Target Species Swine

Species Reactivity Swine

Reproducibility Intra-Assay: CV < 10%; Inter-Assay: CV < 10%

Assay Time Around 270 min

Sample Requirement Serum, plasma, tissue homogenate, cell culture supernatant, cell extract, and other biological fluids.

Target Information

Endoplasmin is encoded by the HSP90B1 gene in pigs. It plays critical roles in folding proteins in the secretory pathway, such as Toll-like receptors and integrins. It has been implicated as an essential immune chaperone to regulate both innate and adaptive immunity. According to reports, the SARS-CoV-2 ORF8L and ORF8S proteins inhibit the production of IFN-I by targeting HSP90B1, which is associated with IRF3. This results in the suppression of the host's antiviral immunity.

Target/Biomarker Porcine HSP90B1

Target Synonym Endoplasmin; 94 kDa glucose-regulated protein; GRP-94; 98 kDa protein kinase; PPK 98; ppk98; Heat shock protein 90 kDa beta member 1; gp96 homolog; HSP90B1; GRP94; TRA1

Gene ID 397191

UniProt ID Q29092

Shipping and Storage

This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).

Documents

Datasheet

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

Chen, J. et al. Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling. Frontiers in cellular and infection microbiology. 2022, 12.