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Mouse Wingless Type MMTV Integration Site Family, Member 2 (WNT2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Wingless Type MMTV Integration Site Family, Member 2 (WNT2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse WNT2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Protein Wnt-2 serves as a ligand for members of the frizzled family of seven transmembrane receptors and operates within the canonical Wnt/beta-catenin signaling pathway. In mice, Wnt2 is expressed in the ventral midbrain, where it facilitates the proliferation and differentiation of dopaminergic neuron precursor cells by activating the Wnt/β-catenin signaling pathway. Wnt2 specifically induces the phosphorylation of LRP5/6 and DVL2/3, leading to the activation of β-catenin, which plays a critical role in SN471 dopaminergic cells. Mice deficient in Wnt2 exhibit a reduction in dopaminergic neuron precursor cells and a decreased number of resultant neurons, underscoring Wnt2's essential role in the development of dopaminergic neurons in the ventral thalamus.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.