Mouse Vascular Endothelial Cadherin (VE-Cadherin) ELISA Kit-Sandwich

Cadherins are calcium-dependent cell adhesion proteins that preferentially interact with each other in a homophilic manner to connect cells, contributing to the sorting of different cell types. Cadherin-5 is particularly important in endothelial cell biology, as it controls the cohesion and organization of intercellular junctions. In mice, Cadherin-5 is crucial for maintaining adhesion between endothelial cells, playing a vital role in angiogenesis and disease-related pathological processes. It is essential for maintaining vascular integrity. The expression and localization of Cadherin-5 are critical for endothelial barrier function. For instance, when stimulated by TNF-α and IFN-γ, Cadherin-5 relocates within the adhesion structures between endothelial cells, reducing adhesion ability and potentially facilitating the passage of plasma proteins and other macromolecules through the endothelial barrier.