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Mouse Vanin 1 (VNN1) ELISA Kit-Sandwich

Name: Mouse Vanin 1 (VNN1) ELISA Kit-Sandwich
SKU: EK6F604
Rating: 5 (1 reviews)

Cat. No.EK6F604

Product TypeAnimal Immunoassay Kits

Size

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Product Overview

BioVenic Mouse Vanin 1 (VNN1) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse VNN1 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.

Specifications

Assay Type ELISA-Sandwich

Specificity The assay kit is specific for Mouse Vanin 1 (VNN1).

Target Species Mouse

Species Reactivity Mouse

Detection Range 15.7-1000 pg/mL

Reproducibility Intra-Assay: CV < 10%; Inter-Assay: CV < 12%

Assay Time Around 90 min

Sample Requirement Serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids.

Target Information

Pantetheinase (also known as Vanin 1) is an amidohydrolase enzyme that specifically hydrolyzes a carboamide linkage in D-pantetheine, thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. In a colitis model, vnn1 knockout mice (vnn1KO) exhibited improved survival and reduced intestinal damage, associated with higher glutathione (GSH) levels and lower expression of inflammatory factors. Additionally, Vanin-1 indirectly stimulates the production of inflammatory mediators by inhibiting the activity of peroxisome proliferator-activated receptor γ (PPAR-γ), thereby modulating inflammatory responses in intestinal epithelial cells.

Target/Biomarker Mouse VNN1

Target Synonym Pantetheinase; Pantetheine hydrolase; Tiff66; Vascular non-inflammatory molecule 1

Gene ID 22361

UniProt ID Q9Z0K8

Shipping and Storage

This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).

Documents

Datasheet

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

Bartucci, Roberta et al. "Vanin 1: Its Physiological Function and Role in Diseases." International journal of molecular sciences vol. 20,16 3891. 9 Aug. 2019.