Mouse Trefoil Factor 1 (TFF1) ELISA Kit-Sandwich

Trefoil factor 1 acts as a stabilizer of the mucus gel that covers the gastrointestinal mucosa, providing a physical barrier against various harmful agents. In mice, TFF1 has several functions, including maintaining the integrity of the gastrointestinal barrier, promoting cell differentiation, inhibiting tumorigenesis, and regulating immune responses. This secreted protein is widely expressed in the gastrointestinal mucosa, particularly in gastric antral cells, and is crucial for preserving the integrity of the gastrointestinal mucosal barrier. Mice lacking TFF1 exhibit compromised gastric mucosal barrier function, which leads to severe inflammatory responses and gastric mucosal damage, including low-grade and high-grade gastric epithelial dysplasia and adenocarcinoma.