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Mouse Transcription Factor A, Mitochondrial (TFAM) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Transcription Factor A, Mitochondrial (TFAM) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse TFAM in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Transcription Factor A, Mitochondrial (TFAM) interacts with the mitochondrial light strand promoter, playing a crucial role in regulating mitochondrial transcription. It is essential for mtDNA replication and transcription, and its deficiency results in profound mitochondrial dysfunction. For instance, mice with a complete TFAM knockout at the whole-body level experience embryonic lethality between E8.5 and E10.5 due to the absence of TFAM protein and a marked reduction or complete loss of mtDNA. Mice with a TFAM knockout specifically in skeletal muscle show significant mitochondrial impairment, characterized by a decreased number of mitochondria, lower mitochondrial DNA copy number, and disrupted function of the respiratory chain complexes.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.