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Mouse Topoisomerase I (TOP1) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Topoisomerase I (TOP1) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse TOP1 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Topoisomerase I alleviates the supercoiling and torsional tension of DNA that occurs during replication and transcription by temporarily cleaving and rejoining one strand of the DNA duplex. It achieves this by introducing a single-strand break via transesterification at a specific site in the DNA. In mice, Top1 binds to DNA to form a topoisomerase I complex (Top1cc), which facilitates the breakage of single-stranded DNA and subsequently relieves DNA superhelical tension. Furthermore, Top1 plays a significant role in the dynamic regulation of chromatin, particularly during neuronal development. Its absence can lead to the accumulation of DNA double-strand breaks (DSBs), which can trigger neurodegenerative diseases.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.