Mouse Toll Like Receptor 7 (TLR7) ELISA Kit-Sandwich

Toll-like receptor 7 (TLR7) is an endosomal receptor vital for both innate and adaptive immunity. It facilitates the host's immune response against pathogens by recognizing uridine-containing single-stranded RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to its agonists, TLR7 undergoes dimerization, bringing the TIR domains from the two molecules into direct contact. This process recruits the TIR-containing downstream adapter MYD88 through a homotypic interaction. In mice, TLR7 primarily contributes to the antiviral immune response, the development of autoimmune diseases, and immune regulation. It functions by recognizing ssRNA and activating the MyD88-dependent signaling pathway, which induces the production of type I interferon and other inflammatory cytokines.