Mouse Toll Like Receptor 3 (TLR3) ELISA Kit-Sandwich

Toll-like receptor 3 is essential for both innate and adaptive immunity. Toll-like receptors (TLRs) regulate the host immune response against pathogens by recognizing microorganism-specific molecular patterns. TLR3 detects nucleotides, specifically recognizing double-stranded RNA, indicative of viral infection. It operates through the adapter protein TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion, and an inflammatory response. In mice, TLR3 is crucial for antiviral and inflammatory regulation by identifying viral dsRNA and activating specific signaling pathways. It detects the dsRNA produced during viral replication, a common pattern across many viruses. Research indicates that TLR3 binds to dsRNA via its extracellular domain, forming a dimer structure that initiates signal transduction.