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Mouse Tissue Inhibitors of Metalloproteinase 2 (TIMP2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Tissue Inhibitors of Metalloproteinase 2 (TIMP2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse TIMP2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) forms complexes with metalloproteinases, including collagenases, and inactivates them irreversibly by binding to their catalytic zinc ion cofactor. In mice, TIMP-2 is essential for regulating the extracellular matrix, tumor growth, angiogenesis, metabolism, and behavior. By naturally inhibiting metalloproteinases, TIMP-2 is crucial for preserving tissue homeostasis and ensuring physiological functions. In a model of Angiotensin II-induced hypertension, mice lacking TIMP-2 exhibited significant changes in glomerular structure and decreased vascular density. This suggests that TIMP-2 is vital for controlling angiogenesis and maintaining the stability of vascular structures.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.