This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Mouse Tamm-Horsfall Glycoprotein (THP) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Tamm-Horsfall Glycoprotein (THP) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse THP in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Tamm-Horsfall glycoprotein (THP) serves various biological functions in mice, including protecting the kidneys from ischemic injury, enhancing phagocyte function, regulating immune responses, exerting antibacterial effects, and preventing kidney stone formation. In a mouse model of renal ischemia-reperfusion injury (IRI), THP demonstrated protective effects. Research indicates that THP stabilizes the outer medullary barrier by reducing inflammatory responses and regulating the expression of Toll-like receptor 4 (TLR4), thus minimizing inflammation and necrosis in renal tissue. Furthermore, THP-/- mice exhibited more severe renal function impairment and inflammation after IRI, reinforcing the significant role of THP in renal protection. THP enhances phagocyte function by activating the MAPK signaling pathway through binding to surface-expressed lactoferrin and prothrombin. Additionally, THP promotes macrophage migration and enhances phagocytic activity.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.