Mouse Soluble Interleukin-2 Receptor alpha chain (IL-2sRa/CD25) ELISA Kit-Sandwich

The Interleukin-2 receptor (IL-2R) is composed of three subunits: α, β, and γ, with the α subunit (IL-2Rα) being crucial for binding to IL-2. IL-2Rα is vital for T cell activation and proliferation, and its expression level is closely linked to the activation state of the immune system. In mice, IL-2Rα expression is regulated by IL-1 and IL-2, involving specific transcription factors and signaling pathways like NF-κB. It can be released into the plasma after binding to IL-2 on the cell surface, resulting in a soluble form of IL-2Rα (sIL-2Rα). The expression and secretion of IL-2Rα in mice are influenced by multiple factors; for instance, triiodothyronine (T3) significantly increases IL-2Rα expression, suggesting a connection to the immune regulation mechanisms associated with thyroid hormones.