Mouse Serglycin (SRGN) ELISA Kit-Sandwich

Serglycin is involved in the formation of mast cell secretory granules and facilitates the storage of various compounds within secretory vesicles. It is essential for storing specific proteases in connective tissue and mucosal mast cells and for storing granzyme B in T-lymphocytes. Additionally, Serglycin aids in the localization of neutrophil elastase within the azurophil granules of neutrophils. In the RIP1-Tag2 mouse model, research revealed that the absence of Serglycin resulted in increased tumor volume and improved tumor vascular function, although there was no notable change in proliferation and apoptosis activities. In tumors lacking Serglycin, there was a decrease in the expression levels of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), suggesting a reduction in the pro-angiogenic capacity of the tumor microenvironment.