Mouse Runt Related Transcription Factor 2 (RUNX2) ELISA Kit-Sandwich

Runt-related transcription factor 2 (RUNX2) is a critical transcription factor involved in the differentiation of osteoblasts and skeletal morphogenesis. It is essential for osteoblast maturation and the processes of both intramembranous and endochondral ossification. In mice, RUNX2's functions extend to bone formation, bone development, tumorigenesis, pulmonary fibrosis, and cardiovascular disease. RUNX2 plays a pivotal role in bone formation, particularly in osteoblast differentiation and bone regeneration. Research has shown that RUNX2 promotes these processes by regulating the differentiation and maturation of osteoblasts. In mouse models, knocking out the RUNX2 gene results in skeletal abnormalities, such as ossification defects and bone deformities, further highlighting RUNX2's crucial role in bone development.