Mouse Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) ELISA Kit-Sandwich

RANTES (Regulated on Activation, Normal T-Cell Expressed and Secreted) is a chemokine that is part of the CCL5 family. It primarily functions by binding to the CCR5 receptor. RANTES plays a significant role in the onset and progression of various diseases, including immune regulation, inflammatory responses, tumor growth, cardiovascular ailments, and neurodegenerative disorders. It has a crucial regulatory function within the immune system. For instance, in a model of cerebral ischemia-reperfusion, RANTES exacerbated brain damage by enhancing leukocyte and platelet adhesion, increasing vascular permeability, and causing tissue damage. Additionally, RANTES demonstrates pro-inflammatory effects in chronic infections such as colitis and Brucella infection, where it can worsen the inflammatory responses.