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Mouse Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse PDK2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (PDK2), is a kinase that plays a crucial role in regulating glucose and fatty acid metabolism and homeostasis by phosphorylating the pyruvate dehydrogenase subunits PDHA1 and PDHA2. PDK2 is important in platelet function, specifically in regulating platelet aggregation and activation. Research has shown that PDK2/4 double knockout mice (PDK2/4−/−) exhibit significant defects in platelet function, including decreased aggregation ability, impaired GPVI-mediated signaling, and reduced calcium ion flow. These defects increase the susceptibility of PDK2/4−/− mice to arterial thrombosis, without noticeably affecting the hemostatic process.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.