Mouse PYD And CARD Domain Containing Protein (PYCARD) ELISA Kit-Sandwich

Apoptosis-associated speck-like protein containing a CARD is a crucial mediator in apoptosis and inflammation. It facilitates caspase-mediated apoptosis, primarily involving caspase-8 and potentially caspase-9, in a cell-type-specific manner. PYCARD is vital for the inflammatory response in mice. Research has demonstrated that PYCARD-deficient mice (Pycard−/−) display significant pathological changes in chronic colitis and tumorigenesis. For instance, in the DSS-induced acute colitis model, Pycard−/− mice showed a notably reduced survival rate and more severe weight loss, while levels of inflammatory markers IL-1β and IL-18 were significantly lowered. This highlights PYCARD's essential role in maintaining inflammatory responses and intestinal barrier function.