Mouse Protein Kinase, AMP Activated Beta 1 (PRKAb1) ELISA Kit-Sandwich

PRKAb1 is a non-catalytic subunit of AMP-activated protein kinase (AMPK), an essential energy sensor that regulates cellular energy metabolism. In response to reduced intracellular ATP levels, AMPK activates pathways that produce energy and inhibits processes that consume energy, such as protein, carbohydrate, and lipid biosynthesis, as well as cell growth and proliferation. Research indicates that Prkab1 is crucial for maintaining red blood cell integrity. For instance, Prkab1-deficient mice demonstrate microcytic anemia, increased resistance to red blood cell osmotic pressure, and splenomegaly, highlighting Prkab1's role in red blood cell morphology and function. Furthermore, Prkab1 influences cell energy metabolism and viability through the regulation of the AMPK signaling pathway.