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Mouse Presenilin 2 (PS2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Presenilin 2 (PS2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse PS2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Presenilin-2 is likely a catalytic subunit of the gamma-secretase complex, an endoprotease complex that facilitates the intramembrane cleavage of integral membrane proteins, including Notch receptors and the amyloid-beta precursor protein (APP). Its protease activity is dependent on the presence of the other gamma-secretase complex members. PS2 plays a crucial role in the γ-secretase complex, which processes APP to generate the neurotoxic amyloid beta peptide (Aβ). Research indicates that mutations or loss of PS2 lead to an accumulation of Aβ, a primary pathological feature of Alzheimer's disease (AD). For instance, a notable increase in Aβ42 levels has been observed in PS2 mutant mouse models, aligning with the pathological traits seen in human AD patients.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.