Mouse Platelet/Endothelial Cell Adhesion Molecule (PECAM1) ELISA Kit-Sandwich

In mice, PECAM-1 is crucial for processes such as angiogenesis, leukocyte migration, thrombosis, immune regulation, and signal transduction. It is prominently expressed at the junctions between endothelial cells, serving as a vital molecule for maintaining vascular integrity and facilitating angiogenesis. Research indicates that PECAM-1 aids in angiogenesis and the formation of new blood vessels through its role in signal transduction and mechanical interactions among endothelial cells. Additionally, PECAM-1 is key in regulating how endothelial cells sense fluid shear forces, thus influencing vascular homeostasis. It plays a pivotal role in the transendothelial migration of leukocytes, which is fundamental to the inflammatory response, enabling leukocytes to move from the bloodstream into the interstitial spaces. PECAM-1 assists leukocytes in traversing the endothelial barrier by interacting with adhesion molecules present on their surface.