Mouse Plasminogen Activator, Urokinase Receptor (uPAR) ELISA Kit-Sandwich

The urokinase plasminogen activator surface receptor (uPAR) serves as a receptor for the urokinase plasminogen activator (uPA) and is crucial in localizing and enhancing plasmin formation. It facilitates the proteolysis-independent activation of signal transduction effects triggered by uPA. In mice, the functions of uPAR (Plaur) encompass various aspects, such as neurodevelopment, immune regulation, disease models, and alterations in behavioral and cognitive functions. uPAR plays a significant role in the development of the mouse brain, with studies indicating that it influences brain maturation by regulating neuronal development and synaptic plasticity. In the hippocampus of mice, those deficient in uPAR demonstrated reduced cognitive flexibility, which is associated with the function of the orbitofrontal cortex (OFC).