Mouse Phosphotylinosital 3 Kinase (PI3K) ELISA Kit-Sandwich

PI3K is a pivotal lipid kinase responsible for phosphorylating phosphatidylinositol (PI) to produce phosphatidylinositol 3,4,5-triphosphate (PI3,4,5-P3), initiating numerous downstream signaling pathways. This process allows PI3K to regulate cell growth, proliferation, and survival by activating pathways such as protein kinase B (PKB/Akt) and mTOR. In mice, PI3K plays a significant role in immune responses. Specifically, the p110δ subunit of PI3K is crucial in regulating B cell proliferation and metabolism, which is vital for mounting protective immunity against parasitic infections like trypanosomiasis. Additionally, PI3K is involved in inflammatory responses in mouse macrophages. For instance, LPS-induced PI3K activation leads to the expression of inflammatory factors such as IL-1β, TNF-α, and interleukin-6, thereby promoting inflammation.