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Mouse Phospholamban (PLN) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Phospholamban (PLN) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse PLN in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Phospholamban serves as a reversible inhibitor of ATP2A2/SERCA2 activity in the cardiac sarcoplasmic reticulum by lowering the ATPase's apparent affinity for Ca2+. It preferentially binds to the ATP-bound E1 conformational form of ATP2A2, which is predominant at low Ca2+ concentrations during the cardiac cycle's diastolic phase. In the mouse heart, the function of phosphorylated phospholamban (PLB) is closely linked to its regulatory impact on myocardial contractility and calcium management. In transgenic mouse models, cardiac-specific overexpression of PLB results in decreased calcium reuptake capacity and diminished myocardial contractility, evidenced by reduced fractional shortening and shortening rate.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.