Mouse Peptidyl Arginine Deiminase Type IV (PADI4) ELISA Kit-Sandwich

Protein-arginine deiminase type-4 (PADI4) facilitates the citrullination or deimination of arginine residues in proteins, such as histones. This process is vital for the histone code and plays a significant role in regulating stem cell maintenance. The PADI4 gene is expressed across various cell types and is modulated by multiple signaling pathways. In rheumatoid arthritis (RA), polymorphisms in the PADI4 gene are linked to increased disease susceptibility. Additionally, PADI4 expression in lung cancer correlates with tumor cell migration and invasion, with its knockout leading to reduced migration and invasion. In mice, PADI4 likely performs similar functions as in humans, including regulating gene expression, contributing to epigenetic modifications, impacting immune responses, and being involved in disease onset and progression.