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Mouse Pancreatic Stellate Cells-Immortalized by SV40T Antigens
Product Overview
Pancreatic stellate cells are found in the interlobular and interacinar spaces of the pancreas. During pancreatic fibrosis, they are activated by various pathological factors and secrete a range of extracellular matrix components, including collagen, thereby initiating and promoting the fibrotic process. Under normal conditions, pancreatic stellate cells are in an inactive, quiescent, and spherical state. These cells were immortalized by lentiviral transduction carrying the SV40 gene, granting them unlimited proliferative capacity. The SV40 T-antigen can alter terminal cell differentiation, induce cells into S-phase, and bypass normal cell cycle checkpoints, thereby achieving immortalization.
Specifications
Target Information
These cells are transformed and stably express the large T-antigen of the simian virus 40 (SV40T antigens) to immortalize the cells and extend their lifespan.
Shipping and Storage
This product is shipped with dry ice. It's recommended to store the product with liquid nitrogen and never in a -20 °C or -80 °C refrigerator. Avoid repeated freezing and thawing of the product.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.