Mouse P-Selectin Glycoprotein Ligand 1 (PSGL1) ELISA Kit-Sandwich

P-selectin glycoprotein ligand 1 (PSGL-1) is a SLe(x)-type proteoglycan that facilitates the rapid rolling of leukocytes over vascular surfaces during the initial stages of inflammation through high-affinity, calcium-dependent interactions with E- and P-selectins. It is crucial for the initial capture of leukocytes. In mice, PSGL-1 is involved in multiple processes, including the inflammatory response, thrombosis, immune cell migration, and adhesion. It plays a vital role by interacting with P-Selectin and other ligands such as E-Selectin and ICAM-1. In a mouse model of delayed-type hypersensitivity (DTH), PSGL-1 mediates the recruitment of Th1 cells to inflammatory sites through its binding to P-Selectin, a process that can be inhibited by anti-PSGL-1 antibodies.