Mouse NitricOxide Synthase 2, Inducible (NOS2/iNOS) ELISA Kit-Sandwich

Nitric Oxide Synthase 2, Inducible (NOS2), produces nitric oxide (NO), a messenger molecule with diverse bodily functions. In macrophages, NO is involved in tumoricidal and bactericidal activities and exhibits nitrosylase activity, mediating cysteine S-nitrosylation of cytoplasmic target proteins such as PTGS2/COX2. In mice, NOS2 primarily regulates immune response, inflammation, and oxidative stress. In a Mycobacterium tuberculosis infection model, NOS2 expression is not crucial for early infection control but may influence the immune response in certain scenarios. Moreover, NOS2 plays a significant role in the experimental autoimmune encephalitis (EAE) model; mice lacking NOS2 have heightened susceptibility to EAE, suggesting that NOS2 contributes to the disease process by regulating neuroinflammation.