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Mouse Nicotinamide-N-Methyltransferase (NNMT) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Nicotinamide-N-Methyltransferase (NNMT) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse NNMT in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Nicotinamide N-methyltransferase (NNMT) facilitates the N-methylation of nicotinamide by utilizing the universal methyl donor S-adenosyl-L-methionine to produce N1-methylnicotinamide and S-adenosyl-L-homocysteine, serving as a primary pathway for nicotinamide/vitamin B3 clearance. NNMT plays a crucial role in regulating cellular methylation potential by consuming S-adenosyl-L-methionine, thereby limiting its availability for other methyltransferases. In mice, NNMT is highly expressed in adipose tissue and liver, with its expression level strongly linked to obesity, insulin resistance, and metabolic syndrome. For instance, NNMT knockout mice on a high-fat diet exhibit weight loss, improved insulin sensitivity, and better blood sugar control.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.