Mouse Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 (NOX2) ELISA Kit-Sandwich

NOX2 (NADPH oxidase 2) plays several roles in mouse models, primarily involving oxidative stress, inflammatory response, neurological function, insulin secretion, and vascular function. As a key member of the NADPH oxidase family, NOX2 is predominantly expressed in endothelial cells, macrophages, and neutrophils. It induces oxidative stress by generating superoxide (O₂⁻) and peroxides like hydrogen peroxide. NOX2 activation is linked to oxidative stress and vascular dysfunction in cerebral vessels. In cases of ischemia-reperfusion injury, NOX2-deficient mice (Nox2−/−) exhibited reduced cerebral edema and infarct volume, as well as higher survival rates. Additionally, NOX2 expression in adipose tissue is correlated with inflammation and insulin resistance. NOX2-deficient mice experienced reduced inflammation and insulin resistance when subjected to a high-fat diet, highlighting its involvement in metabolic disorders.