Mouse Neuronal PAS Domain Protein 4 (NPAS4) ELISA Kit-Sandwich

Neuronal PAS domain-containing protein 4 (Npas4) is a transcription factor found in brain neurons that regulates the excitatory-inhibitory balance within neural circuits and is essential for contextual memory formation in the hippocampus. It plays a crucial role in the structural and functional plasticity of neurons. In particular, the expression of Npas4 in the hippocampus's CA3 region is vital for contextual memory formation. Research indicates that Npas4 enhances the formation of excitatory synapses and the plasticity of neural circuits by regulating specific transcriptional programs, thereby aiding in the encoding and consolidation of long-term memory. In Npas4 knockout mice, synaptic plasticity in the CA3 region is compromised due to the absence of Npas4-mediated transcriptional regulation, leading to deficits in contextual memory.