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Mouse Neurofilament, Light Polypeptide (NEFL) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Neurofilament, Light Polypeptide (NEFL) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse NEFL in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Neurofilaments typically comprise three intermediate filament proteins: NEFL, NEFM, and NEFH, which play a crucial role in maintaining neuronal caliber. They may also collaborate with neuronal intermediate filament proteins PRPH and INA to create neuronal filamentous networks. In mice, the neurofilament light polypeptide (NfL) is essential for the proper formation and maintenance of these neurofilament networks. In a healthy state, NfL helps maintain nerve fibers' structural integrity and supports nerve signal transmission by forming intermediate filaments alongside other neurofilament proteins. However, mutations in the NfL gene, such as the N98S mutation, can disrupt neurofilament networks and result in Charcot-Marie-Tooth disease (CMT) type 2E.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.