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Mouse Neprilysin (NEP) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Neprilysin (NEP) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse NEP in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Neprilysin plays a crucial role in breaking down opioid peptides like Met- and Leu-enkephalins by cleaving a Gly-Phe bond. It also catalyzes the cleavage of bradykinin, substance P, and neurotensin peptides. Neprilysin is a key enzyme in degrading Aβ-amyloid protein (Aβ), and its reduced activity is closely linked to the pathology of Alzheimer's disease (AD). Research indicates that decreased neprilysin activity results in elevated Aβ levels in the brain, thus facilitating the onset of AD. For instance, in a mouse model with the neprilysin gene knocked out, there was a notable increase in brain Aβ levels, accompanied by neuronal damage and behavioral deficits.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.