Mouse Monoamine Oxidase B (MAOB) ELISA Kit-Sandwich

Amine oxidase [flavin-containing] B (MAOB) catalyzes the oxidative deamination of primary and some secondary amines, including neurotransmitters and exogenous amines like the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). This process involves the simultaneous reduction of oxygen to hydrogen peroxide and plays a key role in the metabolism of neuroactive and vasoactive amines within the central nervous system and peripheral tissues. MAOB is a flavin-dependent enzyme primarily responsible for the oxidative deamination of biogenic amine neurotransmitters such as dopamine, norepinephrine, and serotonin (5-hydroxytryptamine). In mice, MAOB specifically degrades β-phenylethylamine (PEA), whereas MAOA mainly degrades serotonin and norepinephrine. This enzyme is widely distributed in the brain, particularly in areas linked to neurotransmitter synthesis and degradation, such as the striatum, hippocampus, and prefrontal cortex.